In vitro activity of LY146032, a new lipopeptide antibiotic, against gram-positive cocci
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چکیده
منابع مشابه
Comparative in vitro activity of DU-6859a, a new fluoroquinolone agent, against gram-positive cocci.
The in vitro activity of DU-6859a (DU), a new fluoroquinolone agent, was evaluated against 233 gram-positive cocci and was compared with those of ciprofloxacin, vancomycin, nafcillin, and ampicillin. The MICs of DU for 90% of the staphylococci tested were < or = 0.06 microgram/ml. All of the groups A and B and viridans group streptococci were inhibited by < or = 0.125 microgram of DU per ml, wh...
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The aim of this review is to summarize the historical background of drug resistance of Gram-positive pathogens as well as to describe in detail the novel lipopeptide antibiotic daptomycin. Pharmacological and pharmacokinetic aspects are reviewed and the current clinical use of daptomycin is presented. Daptomycin seems to be a reliable drug in the treatment of complicated skin and skin structure...
متن کاملIn vitro activity of LY146032 alone and in combination with other antibiotics against gram-positive bacteria.
The antibacterial activity of LY146032 alone and in combination with other drugs was assayed against gram-positive isolates. Synergism was found when LY146032 was combined with netilmicin, amikacin, imipenem, and fosfomycin by both checkerboard and time-kill tests. Indifference predominated when LY146032 was combined with teicoplanin, vancomycin, and rifampin. Under no circumstances and with no...
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than imipenem, meropenem and ceftriaxone. Our findings suggest that against these multidrug-resistant pneumococcal isolates, the ranking of in vitro activity based on MIC90 for the b-lactams would be ME1036 (0.12 mg/L) (most active).imipenem (0.5 mg/L). meropenem (1 mg/L).ceftriaxone (1 mg/L).cefotaxime (2 mg/L).penicillin1⁄4cefepime (4 mg/L).amoxicillin (8–16 mg/L).cefuroxime (16 mg/L).ampicil...
متن کاملIn vitro activity of a novel oxazolidinone, AZD2563, against randomly selected and multiresistant Gram-positive cocci.
The in vitro activity of AZD2563, a novel oxazolidinone, was assessed against 595 Gram-positive cocci, comprising recent surveillance isolates and a collection of resistant (including multiresistant), epidemiologically diverse isolates. The MICs of AZD2563 for staphylococci, pneumococci and enterococci had narrow ranges, 0.25-2 mg/L, with modal MICs of 1 mg/L for staphylococci and pneumococci, ...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1987
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.31.2.340